Abstract The therapeutic landscape in metastatic melanoma has changed dramatically in the last decade, with the success of immune checkpoint inhibitors resulting in durable responses for a large number of patients.For patients with BRAF mutations, combinations of BRAF and MEK inhibitors demonstrated response rates and benefit comparable to those fr
PurposeImage-guided radiation therapy (IGRT) is used to precisely deliver radiation to a tumour to reduce the possible damage to the surrounding normal tissues.Clinics use various quality assurance (QA) equipment to ensure that the performance of the IGRT system meets the international standards set for the system.The objective of this study was to
This article presents an interdisciplinary conception of genre proposed by the Russian philologist from Balashov, Professor Vladimir Serafimovich Vakhrushev.The feasibility of this task can be mainly seen in two aspects.First of all, Vakhrushev conceives genre as an ideal model generating versatile rjr-00001 phenomena not only of discursive, but al
BackgroundPopulation size estimates (PSEs) for hidden populations at increased risk of HIV, including female sex workers (FSWs), isidor oreiller are important to inform public health policy and resource allocation.The service multiplier method (SMM) is commonly used to estimate the sizes of hidden populations.We used this method to obtain PSEs for
By failing to document popular belief in the supernatural attributes of religious sites and by drawing up conservation management plans that fail to attend rjr-00001 to such beliefs, current heritage regimes effectively perform a secular translation of them.I argue that the posthuman turn in the humanities and social sciences, and in particular its